Exclude your app in Windows DEP using registry

Regedit, go to
HKEY_LOCAL_MACHINE\SOFTWARE\Microsoft\Windows NT\CurrentVersion\AppCompatFlags\Layers
add new string value with full path and name to your app as Name
and DisableNXShowUI as a Data, for example:
Value name: c:\path-to-app\appname.exe
Value data: DisableNXShowUI

Group Policy Troubleshooting with GPSVC log

http://blogs.technet.com/b/askds/archive/2015/04/17/a-treatise-on-group-policy-troubleshooting-now-with-gpsvc-log-analysis.aspx

Issues with Google Chrome published in XenApp 6.5

In case of your Google Chrome published in Citrix XenApp 6.5 is unstable, crashed or cannot open any site (even chrome://settings etc.) please follow these steps:

– add –allow-no-sandbox-job parameter to the command line in published application’s properties:
“C:\Program Files (x86)\Google\Chrome\Application\chrome.exe” –allow-no-sandbox-job

– add chrome.exe to below registry entries (create them if they don’t exist):

For the 32-bit version

Key: HKEY_LOCAL_MACHINE\SOFTWARE\Citrix\CtxHook
Value Name: ExcludedImageNames
Type: REG_SZ
Value: chrome.exe

For the 64-bit version

Keys:
HKEY_LOCAL_MACHINE\SOFTWARE\Citrix\CtxHook
HKEY_LOCAL_MACHINE\SOFTWARE\Wow6432Node\Citrix\CtxHook
Value Name: ExcludedImageNames
Type: REG_SZ
Value: chrome.exe

Tested with Chrome 43.0.2357.130 (Official Build)

Ref:

Google Chrome Becomes Unresponsive when Started as Published Application
http://support.citrix.com/article/CTX132057

How to Disable Citrix API Hooks on a Per-application Basis
http://support.citrix.com/article/CTX107825